Mathematical Modeling of Cell Lineages and its Application in Tissue Regeneration and Cancer Progression

Featuring Hamed Youssefpour

Ph.D. Candidate, Materials Science and Engineering

The Henry Samueli School of Engineering, UC Irvine



Abstract:

A multispecies continuum model is developed to simulate the dynamics of cell lineages in tissues and solid tumors. The model accounts for spatiotemporally varying cell proliferation and death mediated by the heterogeneous distribution of oxygen and soluble factors. Together these regulate the rates of self-renewal and differentiation of cells within the lineages. The model enables a quantitative study of the critical feedback processes in normal tissue development and solid tumor progression.



About the Speaker:

Hamed Youssefpour attended California State University, Northridge, completing a B.S. degree in manufacturing engineering systems after prior coursework in materials engineering.  He started his graduate studies in chemical engineering and materials science at the University of California, Irvine, in 2006.   His work has focused on the mathematical modeling of tumor and tissue growth under the supervision of Prof. John Lowengrub